This site is intended for US Healthcare Professionals only.
This site is intended for US Healthcare Professionals only.

For example:

Invasive medical or diagnostic interventions can cause episodes of heterotopic ossification (HO) and permanent reduction or loss of mobility in these patients.1

FOP flare-ups can also be brought on by procedures as dental work, intramuscular (IM) injections.


  1. Kitterman JA, et al. Pediatrics 2005;116;e654.
  2. Kaplan FJ, et al. Best Pract Res Clin Rheumatol. 2008 March ; 22(1): 191–205.


Consequences of Delayed Identification and Diagnostic Errors

In a 2005 publication in Pediatrics,1 Kitterman and colleagues reported that more than half of FOP patients (n=138) surveyed had undergone unnecessary and potentially harmful invasive procedures, and had received inappropriate therapies due to diagnostic errors.

Before their FOP diagnosis:

36 patients experienced surgical removal of bone

14 patients received chemotherapy

7 patients received radiotherapy


  • The average number of years elapsed from initial symptom onset to correct diagnosis1

  • The average number of specialists consulted before the correct diagnosis was made.1

  • The mean age of diagnosis of FOP is between 5.7 to 6.9 years old.1,3

Early diagnostic signs of FOP are congenital malformation of the great toes and episodic soft tissue swelling even before the appearance of heterotopic ossification.

Mistaken or delayed diagnosis can lead to morbidity and can exacerbate the condition through use of inappropriate procedures Preventive measures and precautions can be taken to prevent iatrogenic harm.


  1. Kitterman JA, et al. Pediatrics 2005;116;e654.
  2. Kaplan FJ, et al. Bone Miner Metab. 2008;26:521–530.
  3. Pignolo RJ et al. Bone Miner Res 2016: 31(3) 650-656.


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Please always consult a healthcare professional if you require healthcare advice or if you have any specific concerns regarding Fibrodysplasia Ossificans Progressiva. The information provided here is not intended to replace professional advice. This website has been developed by Ipsen in collaboration with those living with Fibrodysplasia Ossificans Progressiva and the healthcare professionals who care for them. Ipsen would like to thank everyone for their valuable insights and stories. All names used on this website are not necessarily real names. Visit our website for more information about us, or to contact us directly. Website design and development by Kanga Health Ltd. Website reference NON-US-002031 December 2020