Invasive medical or diagnostic interventions can cause episodes of heterotopic ossification (HO) and permanent reduction or loss of mobility in these patients.1
FOP flare-ups can also be brought on by procedures as dental work, intramuscular (IM) injections.
In a 2005 publication in Pediatrics,1 Kitterman and colleagues reported that more than half of FOP patients (n=138) surveyed had undergone unnecessary and potentially harmful invasive procedures, and had received inappropriate therapies due to diagnostic errors.
36 patients experienced surgical removal of bone
14 patients received chemotherapy
7 patients received radiotherapy
Early diagnostic signs of FOP are congenital malformation of the great toes and episodic soft tissue swelling even before the appearance of heterotopic ossification.
Mistaken or delayed diagnosis can lead to morbidity and can exacerbate the condition through use of inappropriate procedures Preventive measures and precautions can be taken to prevent iatrogenic harm.